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Vital signs, ECGs, and physical exams showed no significant changes, and no cases of cancer or serious adverse events were reported over six months of follow-up [42]

3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)

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Many investigations have examined the curative effects of these substances in managing numerous illnesses and conditions (Wehbe et al., 2019)